Rafael Nadal's bid for a 21st Grand Slam came to a halt, while Jennifer Brady came out on top in an All-American battle. These are the Top 5 Photos for Wednesday. 

1

Stefanos Tsistsipas defied the odds when he came back from two sets down to defeat Rafael Nadal,  3-6, 2-6, 7-6 (4), 6-4, 7-5, to reach the semifinals. The 22-year-old Greek is the third player to ever beat the Spaniard after going down by two sets (after Roger Federer and Fabio Fognini).

2

Nadal had been dealing with a back injury that's plagued him his entire stay in Australia, though all credit goes to Tsitsipas for playing lights out the final three sets. 

"I think my physical hold quite well,” Nadal said. “Is true that I probably need a little bit more time because is true that I was in great shape and for 20 days I was not able to practice the way that I expected, not able to play one single match in ATP Cup.”

3

Taking on good friend Jessica Pegula, Brady fought back from a set deficit to reach her second career Grand Slam semifinal, 4-6, 6-2, 6-1. The feat is all the more impressive since Brady was one of the 72 players in hard lockdown. 

4

Though she was struggling with the heat, Karolina Muchova stormed back for a huge upset over world No. 1 Ashleigh Barty, 1-6 6-3, 6-2. The Czech is into her first career Grand Slam semifinal where Brady awaits. 

5

Daniil Medvedev made quick work of his friend and compatriot Andrey Rublev, 7-5, 6-3, 6-2. The Russian will next take on Tsitsipas as he seeks his second career Grand Slam final appearance.