Three days into the Australian Open, the American players you'd expect to comfortably come through the early rounds—Sloane Stephens, Madison Keys and Serena Williams—have done just that.

But also, more good news for U.S. tennis, a cohort of lower-ranked players has pulled off a slew of upsets against seeded players to reach Round 3.

Most notably, Frances Tiafoe knocked off No. 5 seed and Wimbledon and US Open finalist Kevin Anderson in four sets, 4-6, 6-4, 6-4, 7-5.

With his 2017 US Open five-setter against Roger Federer and his 2018 maiden title, in Delray Beach, the 20-year-old has been marked for a breakthrough for a while now. It's looking increasingly that Melbourne could be where it happens.

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On the women's side, remarkably few high seeds have fallen so far, but one big loss was handed out by No. 35 Danielle Collins, who beat 14th seed Julia Goerges in the first round, 2-6, 7-6 (5), 6-4.

And Collins' partner in the doubles draw, 17-year-old junior US Open champion Amanda Anisimova, seized her first two Grand Slam wins without giving up a set, including an emphatic 6-0, 6-2 second-round victory over No. 24 Lesia Tsurenko.

This sets up a blockbuster third-round match versus popular pick to win the tournament Aryna Sabalenka.

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Taylor Fritz came out on top in a tightly contested four-setter with No. 30 seed Gael Monfils, 6-3, 6-7 (8), 7-6 (6), 7-6 (5). The 21-year-old now has the opportunity, or misfortune, of playing 2017 and 2018 champion Federer next.

The highest-ranked American, John Isner, was knocked out in the first round. It's a disappointing blow for the Miami Open champion, except it ended up being good news for the future of U.S. tennis as he lost to fellow American Reilly Opelka. Opelka lost his next match to Thomas Fabbiano in a deciding fifth-set tiebreaker.

Ryan Harrison and Madison Brengle both have shot to join the upset party on Thursday, as does recently crowned 20-year-old Hobart champion Sofia Kenin, who plays top seed Simona Halep.

WATCH: Unseeded
Americans shine
early in Melbourne

WATCH: Unseeded Americans shine early in Melbourne

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