An American man has not won a Grand Slam since the 2003 US Open. The debate for years has been simple—who will be next? It is unclear if any American will have a chance to truly challenge for the title in Melbourne, but there are plenty who could threaten to make the second week.
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Age: 31
Ranking: No. 19
Best Australian Open result: 2010 and 2016, round of 16
Isner had a great chance to make his first quarterfinal run at the Australian Open last year, overcoming Feliciano Lopez to set up a fourth round clash with David Ferrer. Isner would beat the gritty Spaniard in their only other match last year, but Ferrer came away with the win in Melbourne in straight sets.
There is not a player in the world who wants to play Isner on a hard court. The University of Georgia alumnus possesses arguably the greatest weapon in tennis, his serve. It doesn’t matter if he’s playing Andy Murray (who's in his section of the draw) or anyone else—if Isner has a good serving day, he will be able to hang around with any opponent he plays.